Textual indicators of deliberative dialogue: a systematic review of methods for studying the quality of online dialogues

High-quality online dialogues help sustain democracy. Deliberative theory, which predates the internet, provides the primary model for assessing the quality of online dialogues. It conceptualizes high-quality online dialogue as civil, rational, constructive, equal, interactive, and for the common good. More recently, advances in computation have driven an upsurge of empirical studies using automated methods for operationalizing online dialogue and measuring its quality. While related in their aims, deliberative theory and the wider empirical literature generally operate independently. To bridge the gap between the two literatures, we introduce Textual Indicators of Deliberative Dialogue (TIDDs). TIDDs are defined as text-based measures of online dialogue quality under a deliberative model (e.g., disagreement, incivility, justifications). In this study, we identified 123 TIDDs by systematically reviewing 67 empirical studies of online dialogue. We found them to have mid-low reliability, low criterion validity, and high construct validity for measuring two deliberative dimensions (civility and rationality). Our results highlight the limitations of deliberative theory for conceptualizing the variety of ways online dialogues can be operationalized. We report the most promising TIDDs for measuring the quality of online dialogue and suggest deliberative theory would benefit from altering its models in line with the broader empirical literature

Thin, binary liquid droplets, containing polymer: an investigation of the parameters controlling film shape

For the fabrication of P-OLED displays, using inkjet printing, it is important to control the final shape resulting from evaporation of droplets containing polymer. Due to peripheral pinning and consequent outward capillary flow, a ring-like final shape is typically observed. This is often undesirable, with a spatially uniform film usually required. Several experimental studies have shown that binary liquid inks can prevent ring formation. There is no consensus of opinion on the mechanism behind this improvement. We have developed a model for the drying of thin, binary liquid droplets, based on thin-film lubrication theory and solve the governing equations to predict the final shape. White light interferometry experiments are conducted to verify the findings. In addition, we present the results of a linear stability analysis that identifies the onset of a surface tension differential driven instability. If the more volatile liquid is more abundant, an instability becomes increasingly likely.This research has been funded by the Engineering & Physical Sciences Research Council, UK and CASE studentship funding from Cambridge Display Technology Ltd., UK. We thank Dr Mark Dowling of Cambridge Display Technology Ltd., for help with the experimental setup.This is the author accepted manuscript. The final version is available from Cambridge University Press via http://dx.doi.org/10.1017/jfm.2016.16

W3 Constructions on Affine Lie Algebras

We use an argument of Romans showing that every Virasoro construction leads to realizations of $W_3$, to construct $W_3$ realizations on arbitrary affine Lie algebras. Solutions are presented for generic values of the level as well as for specific values of the level but with arbitrary parameters. We give a detailed discussion of the \aff{su}(2)_\ell-case. Finally, we discuss possible applications of these realizations to the construction of $W$-strings.Comment: 9 page

Vacuum Instability in Topologically Massive Gauge Theory

We find the critical charge for a topologically massive gauge theory for any gauge group, generalising our earlier result for SU(2). The relation between critical charges in TMGT, singular vectors in the WZNW model and logarithmic CFT is investigated.Comment: 14 pages, Late

Nanomagnetic domains of chromium deposited on vertically-aligned carbon nanotubes

The drive to create ever smaller magnetic memory devices has led to the development of new nanomagnetic domains on surfaces. This paper reports the development of nano-chromium magnetic domains obtained using electrodeposition on vertically aligned carbon nanofibers arrays. Attempts to achieve this using conventional aqueous solutions were unsuccessful even after thin nickel underlayers were applied. The use of a novel electrolyte, a deep eutectic solvent, made from choline chloride: chromium (III) chloride enabled highly conformal overcoatings of chromium on individual bare carbon nanotubes to be obtained. Very high aspect ratio metal microstructures could be obtained by this novel technology. Magnetic imaging of the coated nanoarrays showed there to be clear magnetic character to the coating when the thin coatings were applied but this disappeared when the deposits were thicker and more contiguous

Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase.

There is an urgent requirement for sustainable sources of food and feed due to world population growth. Aquaculture relies heavily on the fish meal and fish oils derived from capture fisheries, challenging sustainability of the production system. Furthermore, substitution of fish oil with vegetable oil and fish meal with plant seed meals in aquaculture feeds reduces the levels of valuable omega-3 long chain polyunsaturated fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, and lowers the nutritional value due to the presence of phytate. Addition of exogenous phytase to fish feed is beneficial for enhancing animal health and reducing phosphorus pollution. We have engineered the marine diatom Phaeodactylum tricornutum, accumulating high levels of EPA and DHA together with recombinant proteins: the fungal Aspergillus niger PhyA or the bacterial Escherichia coli AppA phytases. The removal of the N-terminal signal peptide further increased phytase activity. Strains engineered with fcpA and CIP1 promoters showed the highest level of phytase activity. The best engineered strain achieved up to 40,000 phytase activity units (FTU) per gram of soluble protein, thus demonstrating the feasibility of development of multifunctionalized microalgae to simultaneously produce industrially useful proteins and fatty acids to meet the demand of intensive fish farming activity

Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology

Particles of cowpea mosaic virus (CPMV) have enjoyed considerable success as nanoparticles. The development of a system for producing empty virus-like particles (eVLPs) of the virus, which are non-infectious and have the potential to be loaded with heterologous material, has increased the number of possible applications for CPMV-based particles. However, for this potential to be realised, it was essential to demonstrate that eVLPs were accurate surrogates for natural virus particles, and this information was provided by high-resolution cryo-EM studies of eVLPs. This demonstration has enabled the approaches developed for the production of modified particles developed with natural CPMV particles to be applied to eVLPs. Furthermore, a combination of cryo-EM and mutagenic studies allowed the development of particles which are permeable but which could still assemble efficiently. These particles were shown to be loadable with cobalt, indicating that they can, indeed, be used as nano-containers

Monitoring the emergence of community transmission of influenza A/H1N1 2009 in England: a cross sectional opportunistic survey of self sampled telephone callers to NHS Direct

Objective To evaluate ascertainment of the onset of community transmission of influenza A/H1N1 2009 (swine flu) in England during the earliest phase of the epidemic through comparing data from two surveillance systems

SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study

BACKGROUND: Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity and efficacy of SARS-CoV-2 vaccines in patients with antibody deficiency is poorly understood. OBJECTIVES: COVID-19 in patients with antibody deficiency (COV-AD) is a multi-site UK study that aims to determine the immune response to SARS-CoV-2 infection and vaccination in patients with primary or secondary antibody deficiency, a population that suffers from severe and recurrent infection and does not respond well to vaccination. METHODS: Individuals on immunoglobulin replacement therapy or with an IgG less than 4 g/L receiving antibiotic prophylaxis were recruited from April 2021. Serological and cellular responses were determined using ELISA, live-virus neutralisation and interferon gamma release assays. SARS-CoV-2 infection and clearance were determined by PCR from serial nasopharyngeal swabs. RESULTS: A total of 5.6% (n = 320) of the cohort reported prior SARS-CoV-2 infection, but only 0.3% remained PCR positive on study entry. Seropositivity, following two doses of SARS-CoV-2 vaccination, was 54.8% (n = 168) compared with 100% of healthy controls (n = 205). The magnitude of the antibody response and its neutralising capacity were both significantly reduced compared to controls. Participants vaccinated with the Pfizer/BioNTech vaccine were more likely to be seropositive (65.7% vs. 48.0%, p = 0.03) and have higher antibody levels compared with the AstraZeneca vaccine (IgGAM ratio 3.73 vs. 2.39, p = 0.0003). T cell responses post vaccination was demonstrable in 46.2% of participants and were associated with better antibody responses but there was no difference between the two vaccines. Eleven vaccine-breakthrough infections have occurred to date, 10 of them in recipients of the AstraZeneca vaccine. CONCLUSION: SARS-CoV-2 vaccines demonstrate reduced immunogenicity in patients with antibody deficiency with evidence of vaccine breakthrough infection